Background This study was undertaken to compare the effect of oxycodone with that of fentanyl in attenuating sympathetic responses induced by tracheal intubation.
Methods Sixty-six ASA physical status I-II patients scheduled for elective surgery requiring general endotracheal anesthesia, were randomly allocated in a blinded fashion to receive an intravenous bolus of either fentanyl 1 mcg/kg or oxycodone 0.1 mg/kg. The systolic blood pressure, diastolic blood pressure, mean arterial pressure and heart rate were measured before induction of anesthesia, before intubation and at 1, 3, 5, and 7 minutes respectively after tracheal intubation.
Results There were statistically significant differences in the results of blood pressures and heart rate in both groups indicating sympathetic response during laryngoscopy and tracheal intubation. However, blood pressures and heart rates significantly increased in Group F compared with those of Group O.
Conclusion Oxycodone caused less variation in arterial pressures and increases in heart rate than fentanyl. It can provide an effective control of the inotropic response induced by laryngoscopy and tracheal intubation.