This study sought to investigate the incidence of mothers who are Hepatitis B surface antigen positive at Camiguin General Hospital for the month of December 2005 and January 2006. This study sought to find out cases of pregnant women with positive hepatitis B surface antigen who delivered at Camiguin General Hospita, number of babies born from mothers who are positive of hepatitis B surface antigen, and were given immunoprophylaxis 12 hours after delivery, and the profile of the mothers who had hepatitis B surface antigen positive as to age, educational status, economic status and awareness of the result of hepatitis B surface antigen. Pregnant women admitted were checked up if they are positive of Hepatitis B surface antigen and the study reveals that out of seventy (70) pregnant mothers admitted and delivered, fifty eight (58) were examined for Hepatitis B surface antigen and twelve (12) were not examined. Three (3) of the mothers were found positive of Hepatitis B surface antigen with three (3) babies born from mothers who are positive for Hepatitis B surface antigen and were given Hepatitis B vaccine with a dose of 0.5 ml and Hepatitis B immunoglobulin with a dose of 0.5 ml at birth. The three mothers are in their early twenties, single, first time mothers, undergraduates and jobless and knew the result of the Hepatitis B surface antigen prior to delivery. The researchers concluded that there might be a bigger population of Hepatitis B surface antigen positive mothers at Camiguin Island but have not been diagnosed. Proper prenatal care to mothers shall be given to minimize cases of Hepatitis B surface antigen, and mandatory examination of Hepatitis B surface antigen to all pregnant women shall be conducted, since prenatal transmission of the disease is the mode of transmission which perpetuates the disease.