Breeding for and subsequent cultivation of tolerant varieties have proved effective in harnessing limiting ecosystems worldwide, which otherwise remain idle. In the humid tropics of Bay islands, about 4,000 ha in valleys remain fallow due to frequent inundation with tidal sea water. Our earlier attempts to cultivate conventionally bred salt-tolerant rice varieties in those areas were only partially successful due to the inherent low yield of available varieties. The potential of in vitro culture-induced variation (somaclonal variation) was explored in developing salt-tolerant rice varieties suitable for such areas. Nine promising somaclones derived from a tall traditional salt-tolerant cultivar Pokkali (Mandal et al 1999) were assessed for their response to different N doses in the wet tropics of Andaman islands. The major objective was to select the most suitable among the somaclones and to determine the optimum level of N requirement to attain maximum yield.