Gross, histopathological and blood examinations were conducted in dogs infested with Sarcoptes scabiei var. canis with and without treatment of gliricidia (Gliricidia sepium). Twenty-five dogs were divided into three treatment groups: 1) Control, without treatment; 2) Gliricidia soap treatment; and 3) Gliricidia decoction treatment. For the latter two groups, gliricidia treatment was given once a week for six weeks. Results showed that the two gliricidia preparations (soap and decoction) reduced the population of mites significantly. After six weeks of treatment, gliricidia-treated dogs had 100% cure rate based on reduction of mites, reduction of gross skin lesions and normalization of hematologic values. Gross evaluation revealed a significant reduction of skin lesions in gliricidia-treated dogs compared with non-treated animals. However, microscopic evaluation revealed no significant reduction of skin lesions among the three groups. Hematologic evaluation revealed a significant improvement (normalization) in gliricidia-treated animals. The results of the study suggest that both soap and decoction preparations of gliricidia are effective in treating sarcoptic mange in dogs.