Plasma transferrin polymorphism was examined from 120 goat blood plasma samples from the Anglo Nubian (AN), Boer (BOR), NatIve Black (NATBl), Native Brown (NATBR), and Native Mixed Color (NATM) breeds, utilizing polyacrylamide gel electrophoresis (PAGE) technique. Three Tf alleles (TfA, TfB and TfC) were identified. The Anglo Nubian and Boer breed groups revealed three transferrin genotypes (TfAA, TfAB, TfBB), while the Native goats exhibited a total of five genotypes (TfAA, TfAB, TfAC, TfBB, and TfBC ). Among the goat breeds studied, estimate of heterozygosity was found to be highest (0.605 ± 0.045) in the Native Mixed Color and lowest (0.362 ± 0.094) in the Anglo Nubian breed. Genetic distances among breed groups studied ranged from 0.00098, between Native Black and Native Brown subgroups, to 0.05122, between Anglo Nubian and Native Mixed Color. The constructed dendrogram showed a cluster between the Native Black and Brown, and another between Boer and Native Mixed Color. The two clusters are distantly related to the Anglo Nubian breed.