A four-year old male domestic shorthair cat was brought to the University of the Philippines Veterinary Teaching Hospital with clinical signs of sneezing and nasal, ocular and gingival discharges. Physical examination revealed ulceration of the nostrils, gingival swelling and a subcutaneous lumbo-sacral lump. Scrapings and impression smears were obtained from the oral and nasal lesions and were submitted for cytologic evaluation. Yeast-like organisms with variably-sized thick capsules resembling soap bubbles were found, confirming the presence of Cryptococcus sp. Initial treatment given before confirmation of the disease included enrofloxacin, meloxicam and ascorbic acid. Fluconazole was given after the disease was confirmed. Prognosis for the case was good, with aggressive treatment and constant monitoring of the patient.