The hematologic profile and biochemical values in adult dogs given nanoliposome-encapsulated malunggay (Moringa oleifera) phenolic extract were determined in this study. Six adult dogs were divided into three groups: Group A: cholesterol only; Group B: cholesterol with malunggay phenolic extract; and Group C: cholesterol with nanoliposome-encapsulated malunggay phenolic extract, with two dogs per group. Each dog was subjected to a complete blood count at weeks 0, 1 and 5 and serum biochemistry tests at weeks 0 and 5. The results showed that thrombocytopenia and a decrease in the elevated blood urea nitrogen level were observed after administration of the nanoliposome-encapsulated malunggay phenolic extract. It also showed below normal cholesterol and low density lipoprotein levels and within normal triglyceride and high density lipoprotein levels after the experiment. These preliminary findings suggest that nanoliposome-encapsulated malunggay phenolic extract may have an effect on the platelets, kidneys, and lipid profile. However, further studies should be done to verify this association.