The effect of administration of nanoliposome encapsulated malunggay (Moringa oleifera) phenolic extract in dogs given cholesterol on body fat and hepatic and renal ultrasonograms was investigated in this study. Six adult male dogs were given cholesterol without (T1) or with non-encapsulated (T2) and nanoliposome encapsulated (T3) malunggay (M. oleifera) phenolic extract. Data on the back fat thickness, body condition score and hepatic and renal ultrasonograms were collected at weeks 0, 1 and 5. Dogs in T3 showed inconsistent changes in the back fat thickness and body condition score. Moreover, T3 dogs exhibited decrease in both hepatic and renal echo mean values. The initial findings suggest that monitoring of the liver and kidney in cases of dyslipidemia or hyperlipidemia should be considered since ultrasonogram results indicate probable development of liver and kidney problems. Further studies are recommended to verify these results.