To detect the presence of Porcine Reproductive and Respiratory Syndrome (PRRS) and Porcine Circovirus Type 2 (PCV2) antibodies from pigs raised in smallholder farms in Sariaya, Quezon, a total of 53 blood samples were collected from pigs in the Sariaya Abattoir, Quezon. Blood sera were harvested and then tested for the presence of PRRS and PCV2 antibodies using indirect enzyme-linked immunosorbent assay. This study revealed that out of 53 serum samples, 8 (15.1%) were seropositive for PRRS and 43 (81.1%) were seropositive for PCV2. Based on origin of serum samples, 5 (41.7%) out of 12 barangays studied in Sariaya, Quezon had PRRS-seropositive samples and 11 (91.7%) out of 12 barangays had PCV2seropositive samples. The results suggest that pigs raised in smallholder farms in some villages in Sariaya, Quezon were infected with these two economically important diseases and can be a threat not only to smallholder farms but also to neighboring commercial farms.