The study evaluated the effects of supplementing non-starch polysaccharides enzyme (NSPE) to a cornsoybean meal based diet with reduced ME and digestible amino acids (DAA) on growth performance, carcass characteristics, and economic return in growing-finishing pigs. A total of 54 barrows (Duroc-Pietrain × Landrace-Large White) with an initial BW of 25.6±1.6 kg were randomly assigned using a completely randomized design to 3 dietary treatments: positive control (PC, formulated under local industry nutrient specifications), negative control (NC, reduced to 65 kcal ME/kg and 1.5% DAA) and NC + NSPE. The NSPE is a commercial preparation (Rovabio Excel AP, Adisseo France) produced from fermentation of nongenetically modified Penicilium funiculosum. The NSPE was added at the rate of 50 g/100 kg of the diet. Each treatment had 6replicate penswith 3pigs per pen. Pigs fed the diet with NSPE had improved (P<0.05) ADG and F:G compared with those fed the PC and NC diets in the starter phase, and tended (P<0.08) to have improved F:G and final weights in the overall phase. There was no indication that the reduction in ME and DAA compromised performance of the pigs. Dietary effects on carcass characteristics were not observed. The inclusion of NSPE to the diet with reduced ME and DAA decreased (P<0.03) cost per kg gain during the starter, grower, and overall phase. In conclusion, results indicate that the NSPE can be used satisfactorily in growing-finishing pig dietswith reduced ME and DAA.