Annabelle A. Ribo | Orcheliza L. Paramo | Mary Jane A. Andong | Lady Angelic C. Cabug | Hannah Deborah A. Gica | Elaine Mae Y. Manug | Lois Andrea M. Pedregosa | Joan C. Quinones | Rujene F. Suaybaguio | Marifel A. Tomas
Diuretics relieve pulmonary congestion and peripheral edema, primarily lower hypertension by decreasing blood volume through the excretion of water in the urine. This study attempts to investigate the urine output increasing activity of the formulated syrup from the fresh and dried ethanolic leaf extracts of Physic Nut (Jatropha curcas L.). Fourier Transform Infrared and Ultraviolet-Visible Spectroscopy analyses revealed to contain organic functional groups of alcohol, unsaturated hydrocarbons and carboxylic acid. The findings may warrant the pharmacological capacity of J. curcas to increase urine output in which it has saponin that induces diuresis. It was also found out that the plant is non-toxic at 2000 mg/kg dose and not mutagenic. Results revealed that the fresh one can effectively increase the urine output at a dose of 158.489 mg/kg and 10 mg/kg for dried one. Copper was detected for both types of extract using Atomic Absorption Spectrometry but within tolerable limits. Bioassay for formulated syrup has no significant difference from the control drug. Therefore, it is recommended to conduct further tests for thorough investigation.