Cancer or malignant tumor is a group of diseases involving abnormal cell growth with the potential to invade or spread other parts of the body. According to World Health Organization 2012, cancer comprises 63% of annual global mortalities, claiming the lives of 7.6 million people each year. In search for anticancer drugs, a study about the angiogenic activity of Bignay (Antidesma bunius) dried leaf extract was further examined and studied. This study focuses on Bignay’s content of polyphenols and its anti-angiogenic role against cancer. To determine the total amount of phenolic acid present, quantitative phytochemical analysis was performed using Folin-Ciocalteau reagent. The result shows 0.65 mg/g being expressed in Gallic Acid Equivalent/g. The median lethal concentration (LC50) as antiangiogenic agent was at 53.71%. Duck Chorioallantoic Membrane (CAM) Assay was conducted to determine the anti-angiogenic property having 10%, 20%, 30%, 40% and 50% concentrations were used for comparison. Result shows that 40% concentration had the greatest anti- angiogenic activity in termsof the decrease number of blood vessels developed against positive control, Bevacizumab. It found out that there was no significant difference between the antiangiogenic effect in high concentration and Bevacizumab as positive control in 3-day old duck chorioallantoic membrane.