This study aimed to determine the level of job satisfaction of hospital pharmacists in the Philippines and Malaysia in relation to their demographic profile, level of awareness and engagement in continuing professional development and their effectiveness in carrying out pharmaceutical care practices in their respective workplace. This quantitative study used the descriptive survey method using a validated self-made questionnaire administered among 200 respondents from hospitals in Davao City, Philippines and Selangor, Malaysia. The data obtained from both locations were analyzed using descriptive and inferential statistics. The findings showed that Filipino and Malaysian hospital pharmacists were satisfied with their jobs. Their awareness to CPD was high but their participation in CPDresearch was very low. The level of pharmaceutical care practices was of great extent. Furthermore, there was no significant difference on the pharmaceutical care practices among the Filipino and Malaysian pharmacists. However, there was a significant low correlation between job satisfaction and pharmaceutical practices and there was a significant association between continuing professional education and pharmaceutical practices.