There is a great challenge to enhance the research publication productivity among faculty of higher education institutions. The goal of this study was to find out the determinants of the research publication productivity of faculty in Higher Education Institutions in Region XI. Thereupon, the results could be used to enhance Higher Education Institution research program. The study made use of the descriptive-correlation design which measured the relationship of demographic profile, research capability and institutional research support to research publication productivity of faculty. A researchermade survey questionnaire consisting of four parts namely faculty demographic profile, research capability, institutional support and publication productivity was utilized. Purposive sampling technique was employed in the study wherein a total of 200 faculty respondents from various higher education institutions participated. Frequency, percentage mean and standard deviation were used together with multiple regression analysis. The findings revealed that the level of research capability among higher education faculty was high while the institutional research support was average. Meanwhile, the publication productivity among Higher Education Institution faculty in Region XI was only at 21%. Moreover, the institutional research support comprising training, research infrastructure and budget allocation significantly influenced the publication productivity of faculty in higher education institutions in Region XI.