This study aimed to determine the mediating effect of self-awareness on the relationship between burnout and psychological well-being of private school teachers. The descriptive-correlational research design was utilized in this study. A total of 344 tertiary school teachers in Region XI were selected as respondents using the purposive sampling technique. Sets of survey questionnaires were utilized to obtain data from the respondents. The mean, Pearson Product-Moment Correlation, and mediation analysis using Sobel z test was used as statistical tools in the study. The results revealed that the overall degree of burnout of teachers was moderate. In particular, the teachers had moderate degree of personal burnout while having low degree of client and work burnout. Similarly, the levels self-awareness, and psychological well-being of tertiary school teachers were at moderate level including its indicators. Moreover, the burnout variable had significant relationship with self awareness and psychological well-being. In the same way, there was a significant relationship between self-awareness and psychological wellbeing of teachers. Furthermore, the mediation analysis using Sobel’s test revealed that self-awareness significantly mediated the relationship between burnout and psychological well-being of tertiary school teachers in Region XI.