This study aimed to determine the extent of certain factors that affect the interest of Grade 10 high school students in their various career choices. There were 325 respondents who were selected through total enumeration sampling technique from the different Teresian Daughters of Mary secondary school in Davao City, Davao Del Norte and Samal Island. This quantitative study utilized the descriptive correlation design. It used percentage mean to determine the extent of effect of personal, family, environmental and school as factors to career choices of the respondents. Pearson r was used to determine the relationship between factors affecting career choice and level of interest to various careers. Furthermore, regression analysis was used to determine the level of interest of the Grade 10 students in their dominant career choices. Findings revealed that the cluster of careers in science profession was the highest dominant career choices. Moreover, level of interest when grouped according to sex was not significant. Furthermore, there was a significant relationship between the environmental factor and the students’ level of interest in terms of being technology skilled, service skilled, and arts skilled.