The study determined the relationship of personality traits and academic performance of students who are children of Overseas Filipino Workers (OFW). This quantitative study utilized the descriptive correlation design. The respondents of the study were the 109 college students who were chosen purposively for this study. They were from three different institutions in Davao City. The research covered the variables within the context of students who are children of Overseas Filipino Workers. The percentages, weighted mean, Pearson r, average mean, and regression analysis were the statistical tools used to analyze the data. The results revealed that in terms of personality traits, agreeableness obtained the highest mean while extraversion had the lowest. Moreover, the level of academic performance of the respondents was good. Furthermore, results showed a significant relationship between openness to experience and academic performance. There was also a significant relationship between neuroticism and academic performance. Lastly, only the openness to experience significantly influenced the academic performance of the children of Overseas Filipino Workers.