This study was conducted to determine the relationship between organizational commitment and 21st century skills among teachers of Caraga South District, Division of Davao Oriental. Descriptive and correlation research designs were utilized in this study. Data were gathered from 100 public teachers of Caraga South District, Division of Davao Oriental. Moreover, sets of adapted survey questionnaire were used as instruments to obtain information from the respondents. Mean was used to find the level of organizational commitment and level of 21st century skills among respondents. Person product moment correlation was used to test the significance of the relationship among the independent and dependent variables. Multiple regression was used to find the domain that best influence 21st century skills. The findings revealed that the overall mean of teachers of Caraga South District in organizational commitment and 21st century skills indicators were high. On the other hand, the affective, continuance, and normative organizational commitment among teachers were highly and significantly correlated to the 21st century skills of teachers. Results showed that normative domain best influences the 21st century skill. Further, there was a significant relationship between organizational commitment and 21st century skills of teachers.