Hypertension has become one of the most leading causes of cardiovascular death and principal growing health problems not only in developing countries but also all over the world. Antihypertensive drugs are expensive and most patients cannot afford to buy medicines to treat their cardiovascular diseases. That is why most people used alternative medicines or medicinal plants to treat hypertension because they are very common remedies and are easily available. This study was conducted to determine the 3-hydroxy-3- methylglutaryl co-enzyme Areductase inhibitory activity of Cilantro (CoriandrumSativum L.), BalbasPusa (Orthosiphonaristatus) and Lemongrass (Cymbopogoncitratus). This research employed quantitative specifically experimental research designs in analyzing the phytochemical constituents of the three ethanolic plant samples using the catalytic domain 3-hydroxy-3-methyl-glutarylcoenzyme A (HMGCoA) reductase, substrate 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) trisodium salt, NADPH and atorvastatin as positive control and sterile water as negative control. Furthermore, this research briefly described the total flavonoids content as quercetin and median inhibitory concentration (IC50) of the three plant extracts. Based on the findings of the study, it could be inferred that the plant material may serve as possible agent against HMG-CoA reductase inhibitory activity.