This study was conducted to evaluate the antiinflammatory potential of cocoa (Theobroma cacao) and pomelo (Citrus maxima) leaf extracts. The methods in the evaluation of the anti-inflammatory potential of the leaf extracts started from plant collection, followed by phytochemical screening, acute dermal toxicity test, mutagenicity and heavy metal test. Also, lipoxygenase inhibition test and gel formulation were employed. Results showed that both cocoa (Theobroma cacao) and pomelo (Citrus maxima) leaf extracts contain flavonoids. All dose levels of the extracts that were applied to the skin were found to be nontoxic. Also, leaf extracts were found to be non-mutagenic. In addition to the toxicologic profiling of the leaf extract, presence of cadmium, mercury and lead were noted to be within allowable limits. The lipoxygenase test revealed that there was a significant difference in the antiinflammatory inhibition of the positive control and the cocoa (Theobroma cacao) and pomelo (Citrus maxima) leaf extracts. The positive control had the highest inflammatory inhibition compared to cocoa (Theobroma cacao) and pomelo (Citrus maxima) leaf extracts. The formulated emulsion-gel of cocoa (Theobroma cacao) and pomelo (Citrus maxima) leaf extracts both had a pH below 7 and both extracts had a decreasing viscosity as the speed was increased.
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