Hyperlipidemia is one great contributory factor to the development of cardiovascular diseases which rank as one of the leading causes of mortality in the whole world. It was the goal of this study to find an alternative treatment to hyperlipidemia by evaluating the antihyperlipidemic activity of Artocarpuscamansi leaf extract on triton X-100 induced hyperlipidemic Sprague-Dawley male rats using the quantitative-experimental design. The leaf extract was also evaluated for its phytochemical constituents and acute oral toxicity using the OECD 425 main test, wherein no animal died during the test, but post toxicity test gross necropsy revealed abnormalities on the kidney, liver and ureter of these animals. The leaf extracts were given at concentrations of 100, 200 and 300 mg/ kg BW for a period of 14 days after which the lipid profile (total cholesterol, triglycerides, HDL and LDL) of the test animals were measured. Results of the bioassay were statistically treated using the one-way ANOVA set at 0.05 level of significance and this gave p-values lesser than 0.05. It was found that the effect of all treatment groups of the extract were comparable to the positive control Atorvastatin in terms of its effect on the serum lipid level.