Learners in this 21st century are moving beyond the basic. This study determined the level of 21st Century Skills among senior high school students of Saint Michael College of Caraga. There were two hundred fifteen grade 12 students chosen as participants of the study using stratified proportionate random sampling. It used the descriptive method and a 40 item- questionnaire adapted from Omayana (2019). The quantitative data utilized weighted mean and standard deviation as statistical tools. The Pearsons’ Product correlation coefficient determined the relationship between academic performance and 21st-century skills, and multiple regression was employed to determine the best predictor. Findings revealed that the participants have a “high†21st-century skills. Also, most of the participants were at the Proficient level concerning their academic performance. Meanwhile, there is no significant correlation exists between academic performance and 21st-century skills. Among the four 21st-century skills, only communication showed a significant relationship to academic performance, while the other three skills manifest no substantial association. On-the-other-hand, communication skill is the best predictor of academic performance. It was recommended that school administrators are encouraged to nurture a conducive teaching and learning environment between and among students and teachers to work hand in hand in providing ways to motivate students’ decisions, actions, and academic and career success