This descriptive-correlational study assesses the psycho-spiritual well-being of junior high school students at Catholic Schools in Central Philippines. Also, it determines the relationship between the said constructs, and at the same, their association between the variables of sex, family structure, birth order, religious affiliation, and church involvement. The data are gathered using Ryff’s Psychological Well-being and Ellison and Paloutzian’s Spiritual Well-being Scale. The findings reveal moderate levels of psychological and spiritual well-being among the respondents. Point biserial shows that a significant relationship existed between the demographics of family structure and psychological well-being and between church involvement and psychological well-being. Rank biserial shows, on the other hand, that there is a significant relationship between family structure and spiritual well-being and between church involvement and spiritual well-being. Also, Spearman Rank Correlation results indicated that there is a relationship between psychological well-being and spiritual well-being.