The primary concern of this study is to develop and try-out the I-CARE support materials for academically at-risk students in Chemistry using experiential, active, and game-based learnings. The study was conducted at Governor Ferrer Memorial National High School-Main, City of General Trias. Cavite from School Year 2017-2018. Purposive sampling technique was employed in which 30 Grade 9 at-risk students were chosen. The descriptive-developmental method of study dealt with the development of materials and validation of I-CARE support materials. Fifteen game-based activities were developed, validated, and further revised to support the materials for intervention sessions. For the introduction and pilot implementation on the use of I-CARE support materials, the researcher facilitated and guided the at-risk students during the remedial teaching session. The developed I-CARE support materials and activities were rated 3.98 by peer evaluators, supporting the characteristics of a VBry acceptable instrument to use in teaching Chemistry concepts and improving the students' achievement, self-esteem, and perception towards instructional materials for Chemistry. Four peer evaluators observed and evaluated the materials during the try-out obtaining a mean score of 3.9D. Furthermore, the respondents of the study strongly agreed on the positive impact of using I-CARE support materials and activities obtaining a rating of 3.D9 using a 20-item perception survey. Therefore, it was recommended that the proposed I-CARE support materials be tried-out by the expert and teachers to other groups of students and those with academic and self- esteem difficulties to determine the usefulness of the instructional materials.