Using Swiss mice and male rabbits as test animals, the researcher studied the leukocyte and the thrombocyte increasing activity of the fresh Yellow Passion Fruit juice. This study was conducted by using two parameters: increase in the leukocyte count and increase in the thrombocyte count. The Acute Oral Toxicity Level of the Yellow Passion Fruit Juice was considered non-toxic as it is labeled Category 5 according to Organization for Economic Cooperation and Development (OECD) Globally Harmonized Classification of Toxicants. The Approximate Effective Dose (AED) of the fruit juice on increasing the leukocytes and thrombocytes ranged from 3.98 to 15.84 mg/kg while the effective dose, ED50 of the population of the male rabbits of the Yellow Passion Fruit juice leukocyte increasing activity was at 11.29 mg/kg body weight and the ED50 in thrombocyte increasing activity was at 11.93 mg/kg body weight. The t-test analysis revealed a significant difference before and after treatment of Yellow Passion Fruit juice suspension on leukocytes while there was no significant difference before and after treatment of Yellow Passion Fruit juice suspension on thrombocytes of male rabbits. It can be inferred that the formulated Passion Fruit juice suspension only possesses an increasing activity on leukocyte count.