The study was conducted and anchored on the concept Darling-Hammond (1999) that teachers who are using a wide repertoire of approaches skillfully (literature- based, lecture and small group work) are typically most successful to influence academic achievement. This study aimed to determine the significant relationship and influence of the utilization of literature-based instruction among teachers to the achievement of students in literature course. Descriptive correlation survey was used in this study. It focuses on the present condition with the purpose of finding new truth and it is valuable in providing facts on which specific judgments may be based. The study was conducted in the University of Mindanao to 400 student-respondents. Mean, Pearson Product Moment Correlation and Linear Regression Analysis were the statistical tools used for the data analysis. The findings of the study are as follows: The level of performance of teacher in the utilization of literature-based instruction was high while the level of achievement of students in literature course was moderate. The study concluded that the performance of teachers on the utilization of literature–based instruction influenced or predicted the achievement of students in literature course.