Changing societies and economies pose novel challenges to the lives and work of secondary school teachers. These challenges affect them in various levels which include their personal, professional and aspirations in life. In the literature, this is understood as the condition of their Quality of Work-Life (QWL). The objective of this study is to examine the essential relationship of QWL and aspirations of secondary school teachers through a descriptive-correlation research design. The study conducted a survey which involved 118 respondents which represent 92 percent response rate. As regards aspirations, the results show that although respondents oftentimes experienced from moderate to high level of aspirations, the overall rating was high. The highest is in self-acceptance, which indicates that the most important aspirations for the respondents are to accept one’s self, having a meaningful life and effectively handle one’s self amidst problems. As for QWL, the respondents oftentimes perceived and experienced a high level of QWL. The highest is in social relevance of work, which indicates that respondents find their job to be challenging, rewarding and meaningful. In conclusion, the correlation analysis shows that there exist a significant relationship between QWL and Aspirations, which results to the rejection of the null hypothesis of this study.