Mentoring is an important aspect in any field of discipline. It fosters an environment for the novice to imbibe the real work setting. This study ascertained the mentoring activities of senior nurses and the performance of nurse trainees. It utilized descriptive–correlational research design using a researcher-made questionnaire. The study was conducted at St. Vincent General Hospital, Cebu City, Philippines. The research subjects were the senior nurses while the respondents were the nurse trainees who underwent a training program. The data were statistically treated using simple percentage, weighted mean and Pearson-r. Based on the findings of the study, the mentoring activities exhibited by the senior nurses include those that reflect their roles as standard prodder, model and envisioner. The respondents’ performance was found to be satisfactory based on the records of Human Resource Department. There was a significant relationship between mentoring activities and performance. The researcher concluded that performance of nurse trainees was dependent on the mentoring activities of the senior nurses. Thus, the researcher recommended implementing a mentorship training course for the senior nurses and monitoring the performance of nurse trainees by requiring very satisfactory rating as the basis for hiring to deliver maximum level of quality patient care.