This study aimed to evaluate the efficiency level of the Tri-fold Instructional Model, a holistic system approach in teaching and learning General Psychology. Its key components: the CD-ROM “General Psychology” Module, online collaboration through the internet and Small-Group Discussions (SGDs) were used in a sample of Information Technology class of Sorsogon State College, Magallanes Campus. The researchers made use of validation techniques and assessments employing descriptive, developmental and quasi-experimental methods in a one-group pretest-posttest design. As an innovative instructional tool, the was very much accepted and proven efficient in enhancing mastery learning of students taking the course. There was a significant difference from the previously fair performance of the students as compared to the excellent performance level after the intervention. Teaching, learning and technology therefore work together for efficient knowledge transfer. The Tri-fold Instructional Model as a holistic systems approach is a key to effective instruction. Gauging the students’ learning styles, proper planning of the course content and effective use of technology tools are instruments to successful teaching- learning process.