A Study Guide was tailored to the students of De La Salle and was used as Study Partner. This employs the inquiry- based instruction through the 5 E’s of science lesson: Engage, Explore, Explain, Extend and Evaluate. The descriptive method of research was used in the study to determine the efficacy of the use of Study Partner in the manifestation of science and language skills among the respondents and its relationship to the grade of the students. Results showed that the use of the Study Partner in Human Anatomy and Physiology had been contributory to the enhancement of the language and science skills of the students. The use of the Study Partner had developed a process, reasoning and the critical thinking skills of the students as well as the reading and writing skills. A significant contribution is in the development of the critical thinking skills in science and the reading and writing skills in the language area. The process skills and the critical thinking skills developed were also found to have significant contribution to the final grade of the students in Human Anatomy and Physiology.