Climate change has been known to exert influence on agri-business. This study is an attempt to look into the direct and indirect economic impact of climate change to three (3) business sectors: tourism, commercial and agricultural, of Zamboanga del Norte by canonical path analysis. Results revealed that temperature and rainfall variations led to a decline in agricultural productivity (-1.90%) but spurred greater economic activities in the commercial (47.0%) and tourism sectors (17.12%). The traditional farming method commonly used in the province accounts for the adverse sensitivity of this sector to climate change. This study recommends that the agricultural sector looks into possibilities of using modern farming systems in order to counter the negative consequences brought about by climate change.