Philippine E-Journals

Anti-Inflammatory Effect of the Formulated Tablet of Dalangita (Citrus Nobilis) Peel Extract in Albino Rats

Ma. Corazon S. Loquellano | Rochell V. Canete | Hazel M. Gargoles | Janson Jesson B. Palarisan | Joyce A. Pelaez

Discipline: Chemistry, Pharmacology

 

Abstract:

Plants with its medicinal property alleviate the suffering of many people, in as much as they are used to treat many diseases like, rheumatoid arthritis. With this study, it aimed to determine the inhibitory effect of the formulated tablet from dalangita peel extract (Citrus nobilis) in the paw edema of carrageenan-induced albino rat. Experimentation utilized three Swiss mice administered with the dose level of 2000 mg/ kg body weight following the Acute Single Toxicity Test. Likewise, six healthy male albino rats were with these doses starting at 10mg/kg to 630.96 mg/kg body weight for Approximate Effective Dose (AED). Formulated tablet for bioassay contained 40 mg/kg dose of dalangita peel extract. Bioassay results show that the percentage inhibition in formulated ointment is 32%, Etoricoxib (positive control) is 45.32% while negative control (placebo) is 0.73%. This reveals that at 0.05% level of significance, the test group animal treated with formulated tablet show decrease in paw edema, which only developed for 4 hours after treatment, and similar result was observed with Etoricoxib. However, test animals that received placebo drug manifested a minimal decreased in paw edema. Analysis of variance and Tukey’s multiple comparison test proved that both positive control and dalangita peel extract did not differ significantly with each other. This implies that the peel extract tablet has an equal effect with Etoricoxib in lowering the formation of paw edema on the albino rats