This study was designed to investigate the effects of the formulated Green Caviar (Caulerpa lentillifera J. Agardh) seaweed extract in lowering total cholesterol, triglyceride and low density lipoprotein levels in 15 rabbits fed on high-cholesterol/high-fat diets. Ethanolic extract was determined on its Acute Oral Toxicity using female albino rabbits and Approximate Effective Dose (AED) using male rabbits. Meanwhile, Effective Dose (ED90) was determined within AED range using Algebraic Probit analysis using hypercholesterolemia-induced rabbits. Bioassay for formulated tablet was obtained through dividing 3 groups of rabbits. Group 1 was administered with the formulated Green caviar tablet, group 2 with placebo and 5 mg/kg dose of Simvastatin (positive control) for group 3. Rabbits on the high cholesterol fat diet had significantly increased plasma total cholesterol (TC), plasma low-density lipoprotein cholesterol (LDL-C), plasma triglycerides (TG) in 30 days. Animals treated with Simvastatin showed decrease in total cholesterol, triglycerides and LDL level at 1.1475 ± 0.7030, 1.0775 ± 01.2224 and 0.76 ± 0.7109 respectively. Those that received the formulated test drug have shown positive response towards the treatment as indicated in the decreased of values in these parameters. Total cholesterol, triglycerides and LDL lowered by the experimental group was found to be at 1.36 ± 0.1627, 1.1725 ± 0.7444 and 0.13 ± 0.4567. Statistical analysis showed that there is no significant difference in the total cholesterol, triglyceride and low-density lipoprotein lowered by the formulated Green Caviar tablet and Simvastatin.