HomeFatima University Research Journalvol. 5 no. 1 (2013)

The Effect of Mangifera indica (Mango) Leaf Crude Extract in the Wound Healing Properties of Rattus norvegicus (Sprague Dawley)

Jose Jurel M. Nuevo | Emerson Ronald K. Bernardino

Discipline: Health, Natural Sciences, Medicine

 

Abstract:

This study was conducted to evaluate the effects of Mangifera indica (Mango) leaf crude extract on the wound healing properties of Rattus norvegicus (Sprague Dawley). The phytochemical components, bioactivity and wound healing potentials of Mangifera indica leaf crude extract in the wound healing properties of Rattus norvegicus, The wound healing property of Mangifera indica is attributed to a certain phytochemical constituents mainly tannins, which can facilitate the processes of healing by increasing collagen formation and epithelization.

 

The male Rattus norvegicus was divided into three groups was inflicted by excising a full thickness wound created on the predetermined dorsal nape area via surgical procedure. The three groups were treated topically with Bactroban, sterilized distilled water and the leaf crude extract of Mangifera indica once a day from day 0 to 14. Macroscopically, the wounds were evaluated and the measurement were compared by using Mann-Whitney Test to show the significance between the wound size treated with Bactroban and Mangifera indica leaf crude extract and also by comparing the wound size treated with Mangifera indica leaf crude extract and the negative control (sterile distilled water). The Mangifera indica leaf crude extract had significantly (p<0.05) promoted wound healing compared to the positive and negative controls.